The PHIND Study – Identifying inflammatory subphenotypes in a real-world clinical setting
Retrospective analyses have identified two biologically distinct subphenotypes (hyperinflammatory and hypoinflammatory) of acute respiratory distress syndrome (ARDS), with differing outcomes and responses to therapy. Rapid identification of these subphenotypes in an actionable timeframe has previously not been possible.
MultiSTAT Breaks New Ground in Critical Care Research
The PHIND Study is the first large, multicentre, observational study with the aim of prospectively identifying inflammatory subphenotypes in a real-world clinical setting. The study shows for the first time, that inflammatory subphenotypes of ARDS can be prospectively identified in real time at the bedside using (the MultiSTAT) near-patient immunoassay.
The study establishes the feasibility and reliability of near-patient cytokine measurement for prospective subphenotyping across multiple centres, delivering reliable and reproducible results.
MultiSTAT is a Major Step Toward Precision Medicine in ARDS
These findings establish a foundation for precision medicine in ARDS by identifying subphenotypes that enable tailored interventions. Real-time bedside identification using the MultiSTAT facilitates enriched clinical trials and advancing a shift from a one-size-fits-all model to subphenotype-driven therapies aimed at improving patient outcomes.